Notch transcriptional target tmtc1 maintains vascular homeostasis.

Paik NY, Neethling J, Anwar M, Gupta P, Sanborn MA, Shen Z, Bandara T, Hyun J, Naiche LA, Kitajewski JK, Rehman J, Shin JW, Mehta D, Pajcini KV.

Cellular and Molecular Life Science (2024). Full Text

Hematopoietic Jagged1 is a fetal liver niche factor required for functional maturation and engraftment of fetal hematopoietic stem cells.

Shao L, Paik NY, Sanborn MA, Bandara T, Vijaykumar A, Sottoriva K, Rehman J, Nombela-Arrieta C, Pajcini KV.

Proceedings of the National Academy of Sciences of the United States of America (2023). Full Text

Notch1 and Notch4 core binding domain peptibodies exhibit distinct ligand-binding and anti-angiogenic properties. 

Sargis T, Youn SW, Thakkar K, Naiche LA, Paik NY, Pajcini KV, Kitajewski JK.

Angiogenesis (2023). Full Text

The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages. 

Toboz P, Amiri M, Tabatabaei N, Dufour CR, Kim SH, Fillebeen C, Ayemoba CE, Khoutorsky A, Nairz M, Shao L, Pajcini KV, Kim KW, Giguère V, Oliveira RL, Constante M, Santos MM, Morales CR, Pantopoulos K, Sonenberg N, Pinho S, Tahmasebi S.

Proceedings of the National Academy of Sciences of the United States of America (2022). Full Text

A Notch/IL-21 signaling axis primes bone marrow T cell progenitor expansion. 

Sottoriva K, Paik NY, White Z, Bandara T, Shao L, Sano T, Pajcini KV.

JCI Insight (2022). Full Text

Notch1 promotes ordered revascularization through Semaphorin 3g modulation of downstream vascular patterning signalling factors.

Hyun J, Lee M, Rehman J, Pajcini KV, Malik AB.

Journal of Physiology (2022). Full Text

Notch Signaling in the Bone Marrow Lymphopoietic Niche. 

Sottoriva K, Pajcini KV.

Frontiers in Immunology (2021). Full Text

The neurotransmitter receptor Gabbr1 regulates proliferation and function of hematopoietic stem and progenitor cells. 

Shao L, Elujoba-Bridenstine A, Zink KE, Sanchez LM, Cox BJ, Pollok KE, Sinn AL, Bailey BJ, Sims EC, Cooper SH, Broxmeyer HE, Pajcini KV, Tamplin OJ.

Blood (2021). Full Text

Comprehensive transcriptomic profiling reveals SOX7 as an early regulator of angiogenesis in hypoxic human endothelial cells. 

Klomp J, Hyun J, Klomp JE, Pajcini KV, Rehman J, Malik AB.

Journal of Biological Chemistry (2020). Full Text

Dlk1-Mediated Temporal Regulation of Notch Signaling Is Required for Differentiation of Alveolar Type II to Type I Cells during Repair. 

Finn J, Sottoriva K, Pajcini KV, Kitajewski JK, Chen C, Zhang W, Malik AB, Liu Y.

Cell Reports (2019). Full Text

Notch signaling in mammalian hematopoietic stem cells.

Pajcini KV, Speck NA, Pear WS.

Leukemia 2011 25:10 25, 1525–1532 (2011). Full Text